Vitamin D intake did not impact secondary outcomes
Death from cancer: HR 0.83 (95% CI, 0.67 to 1.02)
Breast cancer: 1.02 (95% CI, 0.79 to 1.31)
Prostate cancer: 0.88 (95% CI, 0.72 to 1.07)
Colorectal cancer: 1.09 (95% CI, 0.73 to 1.62)
Myocardial infarction: 0.96 (95% CI, 0.78 to 1.19)
Stroke: 0.95 (95% CI, 0.76 to 1.20)
Death from cardiovascular causes: 1.11 (95% CI, 0.88 to 1.40)
There was no difference in death from any cause
HR 0.99 (95% CI, 0.87 to 1.12)
No excess risks of hypercalcemia or other adverse events were identified
Effects did not vary according to baseline serum 25-hydroxyvitamin D levels
Supplementation with vitamin D does not reduce risk for cardiovascular disease or invasive cancer in an otherwise healthy population
Authors acknowledge that while the study was appropriately powered for the primary endpoints, longer follow-up would be necessary to truly determine risk for cancer development and would need greater ‘n’ for site specific cancers
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