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#Grand Rounds

The Missing Link between Coffee and Neuroprotection: Is it the Caffeine or Another Component?

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BACKGROUND AND PURPOSE:

  • Coffee is associated with decreased risk of Alzheimer’s disease (AD) and Parkinson’s disease (PD)
  • Mancini et al. (Frontiers in Neuroscience, 2018) sought to determine whether compounds found in brewed coffee may elicit neuroprotective effects by inhibiting the aggregation of amyloid-beta (Aβ) and tau (AD) or α-synuclein (PD)

METHODS:

The study tested the impact of

  • 3 instant coffee extracts
    • Light roast | Dark roast | Decaffeinated dark roast
  • 6 coffee components
    • Caffeine
    • Chlorogenic acid
    • Quinic acid
    • Caffeic acid
    • Quercetin
    • Phenylindane
  • Investigators measured components ability to inhibit the fibrillization of Aβ and tau proteins

RESULTS:

  • Instant coffee extracts (all roast levels)
    • Inhibit fibrillization of Aβ and tau
    • Promote α-synuclein oligomerization
  • Dark roast coffee extracts are more potent inhibitors of Aβ oligomerization
  • Pure caffeine has no effect on Aβ, tau or α-synuclein aggregation
  • Chlorogenic acid, Caffeic acid and Quercetin inhibit the fibrillization of Aβ
  • Only Quercetin inhibits Aβ oligomerization
  • Phenylindane is a potent inhibitor of both Aβ and tau fibrillization, and also inhibits Aβ oligomerization
  • Caffeic acid and Quercetin promote the aggregation of α-synuclein at concentrations
    • No other coffee components affect α-synuclein oligomerization

CONCLUSION:

  • Coffee components may be neuroprotective through their interaction with Aβ and tau aggregation
  • Phenylindane was identified as a dual-inhibitor of both pathogenic Aβ and tau aggregation

Learn More – Primary Sources:

Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation

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Related ObG Topics:

Can We Lay the Coffee and Mortality Debate to Rest?
The Intersection of Coffee and Genetics: Is There an Impact on Mortality?
Does Drinking Coffee Speed Gut Recovery Post GYN Surgery?

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