• About Us
    • Contact Us
    • Login
    • ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
About Us Contact Us Login ObGFirst
  • COVID-19
  • Alerts
  • OB
  • 2T US Atlas
  • The Genome
  • GYN
    • GYN
    • Sexual Health
  • Primary Care
  • Your Practice
  • GrandRounds
  • My Bookshelf
  • Now@ObG
  • Media
Grand Rounds

Vitamin D Levels: Is There an Association with Livebirth and/or Miscarriage

image_pdfFavoriteLoadingFavorite

BACKGROUND AND PURPOSE:

  • Research suggests that serum 25-hydroxyvitamin D (Vitamin D) levels play a role in reproduction
    • Receptors found in important tissues required for normal reproduction
    • Vitamin D may be associated with the immune system
  • Data on this topic limited in humans and generally to IVF/fertility centers
  • Mumford et al. (The Lancet Diabetes & Endocrinology, 2018) examined the association between preconception vitamin D and livebirth/miscarriage among women without fertility issues

METHODS:

  • Secondary analysis of prospective cohort from randomized, double-blind, placebo-controlled trial (RCT)
    • Data from Effects of Aspirin in Gestation and Reproduction (EAGeR) trial
    • Initial trial assessed effects of aspirin on pregnancy loss
  • Participants
    • 18-40 years of age
    • 1 or 2 previous pregnancy losses
  • Vitamin D was measured at
    • Baseline (preconception)
    • 8 weeks of gestation
  • Vitamin D level cut-offs
    • Sufficient concentrations: ≥75 nmol/L
    • Insufficient concentrations: <75 nmol/L
  • Primary outcomes
    • Clinical pregnancy
    • Time to pregnancy (Fecundability)
    • Pregnancy loss
    • Livebirths

RESULTS:

  • 1,191 women were included in the study with data available on preconception 25- hydroxyvitamin D concentrations
    • 47% sufficient
    • 53% insufficient
  • When compared to women with insufficient Vitamin D, women with sufficient preconception Vitamin D were more likely to achieve
    • Clinical pregnancy: adjusted risk ratio (RR) 1.10; 95% CI, 1.01–1.20
    • Livebirth: aRR 1.15; 95% CI, 1.02–1.29
  • Among women who achieved pregnancy, sufficient Vitamin D was associated with reduced risk of pregnancy loss at preconception but not at 8 weeks gestation
    • Preconception: RR per 25 nmol/L 0.88; 95% CI, 0.77–0.99
    • 8 weeks: RR per 25 nmol/L 0.98; 95% CI, 0.95–1.01
  • There was no association between fecundability with sufficient versus those with insufficient preconception VitD levels

CONCLUSION:

  • Sufficient levels of Vitamin D before conception (but not in early pregnancy) are associated with increased likelihood of pregnancy and livebirth
  • Vitamin D levels did not affect time to pregnancy, in keeping with previous research

Learn More – Primary Sources:

Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study

image_pdfFavoriteLoadingFavorite

< Previous
All Grand Rounds Posts
Next >

Related ObG Topics:

Does Vitamin D Intake Decrease the Risk for Gestational Diabetes Mellitus?
(Cochrane 2016) Vitamin D During Pregnancy and Adverse Pregnancy Outcomes
Are Vitamin D Levels Linked to Preeclampsia and Preterm Birth?

Sections

  • COVID-19
  • Alerts
  • OB
  • GYN
    • GYN
    • Sexual Health
  • 2T US Atlas
  • The Genome
  • Primary Care
  • Your Practice
  • Grand Rounds
  • My Bookshelf
  • Now@ObG
  • Media

Are you an
ObG Insider?

Get specially curated clinical summaries delivered to your inbox every week for free

  • Site Map/
  • © ObG Project/
  • Terms and Conditions/
  • Privacy/
  • Contact Us/
© ObG Project
SSL Certificate


  • Already an ObGFirst Member?
    Welcome back

    Log In

    Want to sign up?
    Get guideline notifications
    CME Included

    Sign Up

Get Guideline Alerts Direct to Your Phone
Try ObGFirst Free!

Sign In

Lost your password?

Sign Up for ObGFirst and Stay Ahead

  • - Professional guideline notifications
  • - Daily summary of a clinically relevant
    research paper
  • - Includes 1 hour of CME every month

ObGFirst Free Trial

Already a Member of ObGFirst®?

Please log in to ObGFirst to access the 2T US Atlas

Password Trouble?

Not an ObGFirst® Member Yet?

  • - Access 2T US Atlas
  • - Guideline notifications
  • - Daily research paper summaries
  • - And lots more!
ObGFirst Free Trial

Media - Internet

Computer System Requirements

OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Jointly provided by

NOT ENOUGH CME HOURS

It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan

Subscribe

JOIN OBGFIRST AND GET CME/CE CREDITS

One of the benefits of an ObGFirst subscription is the ability to earn CME/CE credits from the ObG entries you read. Tap the button to learn more about ObGFirst

Learn More
Leaving ObG Website

You are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website. Therefore, we are not responsible for the content or availability of this site