Is there a Causal Link between Vitamin D and Gestational Hypertension / Preeclampsia?
BACKGROUND AND PURPOSE:
Vitamin D, 1,25-dihydroxyvitamin D3 (Vitamin D) can suppress renin biosynthesis and regulate implantation
Therefore, may impact gestational hypertension and/or preeclampsia
Previous literature on the relationship between low Vitamin D concentration and gestational hypertension/preeclampsia is inconclusive
‘Mendelian randomization’ is a technique that assesses genetic variants that impact pathways
Genetic variants are random events at the time of conception, not likely to be impacted by bias
Magnus et al. (BMJ 2018) sought to determine whether low Vitamin D concentration has a causal effect on gestational hypertension or pre-eclampsia using knowledge of genetic variants that impact Vitamin D pathways
One and two sample mendelian randomization analysis
Such analyses can be used to determine possible causal relationships
‘One Sample’ mendelian randomization analysis
Assesses the genetic variants along the vitamin D pathway and outcomes (gestational hypertension and preeclampsia) in the same individual
‘Two Sample’ mendelian randomization analysis
Results from genome studies are used to determine how the variants impact Vitamin D levels and assess whether variants that result in lower Vitamin D levels are associated with higher risk for gestational hypertension or preeclampsia
Vitamin D levels were measured in serum and plasma, and adjusted based on seasons and categorized based on Endocrine Society recommendations
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan