Can Anti-Müllerian Hormone Levels Predict Menopause?
BACKGROUND AND PURPOSE:
Concentrations of hormones involved in ovulation can be used as markers to assess ovarian reserve.
This study by Kim et al. (Maturitas, 2017) sought to examine whether anti-Müllerian hormone (AMH) levels, follicle stimulating hormone (FSH) levels and antral follicle count (AFC) can be used to predict the start of menopause
Retrospective Cohort Study
426 women from the Coronary Artery Risk Development in Young Adults Study (CARDIA) were included
Mean age 43 years old at time of measurements
Serum measurements of AMH and FSH were taken, and the women underwent transvaginal ultrasounds
For women age 45-49 years old, menopause occurred within 5 years if
undetectable levels of AMH was associated with a >60% chance of menopause within 5 years
approximately 30% of women with one or no antral follicles began menopause within 5 years
Low and high concentrations of FSH were associated with increased chance of menopause compared to intermediate levels of the hormone
Age and a single marker were sufficient to predict onset of menopause
AMH, FSH, and AFC can all be used to predict menopause
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