Does Aspirin Decrease the Risk of Preterm Birth in Preeclampsia?
This study by van Vliet et al. (Obstetrics Gynecology, 2017) sought to determine if antiplatelet agents reduce the risk of spontaneous preterm birth.
Systematic Review and Meta-Analysis
17 studies, including 28,797 women, which randomized women to receive low-dose aspirin/dipyridamole vs. placebo/no treatment to prevent preeclampsia were reviewed. Women in the antiplatelet treatment group had lower risk of spontaneous preterm birth at < 37 weeks and <34 weeks than women in the placebo and no treatment groups. The difference was more marked in women who had a previous pregnancy. The authors conclude that antiplatelet treatment is effective in decreasing the risk of spontaneous preterm birth in the setting of preeclampsia.
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