Does cfDNA in First Trimester Signal Subsequent Preeclampsia?
This study by Silver et al. (American Journal of Perinatology, 2017) sought to determine if a relationship exists between first trimester cell-free total DNA in maternal plasma and the development of preeclampsia.
Nested Case-Control Study
Data on 350 women, 50% with and 50% without preeclampsia, who were enrolled in the Combined Antioxidant and Preeclampsia Prediction Studies, were analyzed. While some women did have higher cell-free total DNA than others (Black and Hispanic women had higher levels than white women), there was no correlation between levels and subsequent development of preeclampsia. The authors conclude that cfDNA is not a good prenatal risk assessment marker for preeclampsia.
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