Is there a Link Between Oral Contraception Use and Cancer Risk?
This study by Iversen et al. (AJOG, 2017) sought to explore the relationship between oral contraceptive use and cancer risk.
Prospective Cohort Study
46,022 women were recruited for this study between 1968-1969 and were followed up for 44 years. Long term users of combined oral contraceptives were compared to women who had never used. 4,661 of the 884,895 (0.005%) ever users had at least one cancer, compared to 2,341 of the 388,505 (.006%) never users. Ever use of oral contraceptives was associated with lower incidences of colorectal, endometrial, ovarian, and lymphatic and hematopoietic cancers. Increased risk of breast and cervical cancer was seen in current and recent users, but appeared to be lost within five years of stopping oral contraception, with no further increased risk in either of these cancers over time. This long-term study found that the majority of women taking oral contraceptives do not have an increased risk for cancer, and many benefit from reductions in risk of certain cancers.
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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