Recurrent pregnancy loss (RPL) is defined by two more failed clinical pregnancies. A clinical pregnancy is a pregnancy that has either been documented by ultrasonography or histopathological examination. Most cases of RPL will have no known underlying cause, although the majority of miscarriages are thought to be genetic. Less than 5% of women will experience two consecutive miscarriages, and 1% experience three or more, making it a relatively rare condition.
Note: Aneuploidy risk is lower in women with RPL vs sporadic miscarriage | In sporadic miscarriages vs RPL, 60% of early pregnancy losses have chromosomal anomalies, most of which are trisomies
Antiphospholipid Syndrome (APL)
Etiologies not associated with RPL
Do not screen for
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