Stratified based on baseline provoked pelvic muscle pain severity scores
56 pain-free control subjects, matched by age and race, also completed Female Sexual Function Index (FSFI) for comparison to determine if sexual function in women with PVD would be similar either before or after treatment
230 women were screened at 3 academic institutions
Gabapentin was more effective than placebo in improving
Overall sexual function: Adjusted mean difference (MD) 1.3 (95% CI, 0.4-2.2; P=.008)
Desire: MD 0.2 (95% CI, 0.0-3.3; P=.04)
Arousal: MD 0.3 (95% CI, 0.1-0.5; P=.004)
Satisfaction: MD 0.3 (95% CI, 0.04-0.5; P=.02)
Despite improvement, function remained significantly lower than matched vulvodynia pain-free control subjects
No improvement seen for orgasm, lubrication, or pain domains
Gabapentin improved outcomes in women with high but not low pelvic muscle pain severity scores
Full Female Sexual Function Index scale: MD 1.6 (95% CI, 0.3-2.8; P=.02)
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