Validated 11-point numeric rating scale ranging from 0 (no pain) to 10 (worst pain)
Sexual intercourse and daily pain were also recorded on an 11 point (0-10) numeric rating scale
Mean pain intensity on the tampon test (tampon insertion and removal test used as a surrogate marker for dyspareunia) during the last 7 days of the maintenance phase
Sexual intercourse pain and daily pain
89 women participants were randomized
There was no difference in tampon test pain with gabapentin vs placebo (P=.07)
Adjusted mean 4.0 vs 4.3; difference −0.3 (95% CI −0.7 to 0.0)
Similarly, there was no improvement with gabapentin vs placebo for
Sexual intercourse pain (P=.76)
Daily pain (P=.36)
Subset analyses found that longer pain duration and oral contraceptive nonuse were associated with minimal improvement in tampon test pain with gabapentin
Gabapentin did not reduce tampon test pain, compared to placebo
The authors state
Because previous RCTs studying pharmacologic management options also have been negative, practitioners may want to consider all therapeutic options, including nonpharmacologic management interventions such as physical therapy and behavioral and sexual counseling.
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