(Cochrane 2016) Vitamin D During Pregnancy and Adverse Pregnancy Outcomes
This study De-Regil et al. (Cochrane Review, 2016) aimed to determine if oral Vitamin D, alone or in combination with other vitamins and minerals decreased the risk of adverse pregnancy outcomes.
This review surveyed 15 studies with a total of 2,833 women, and found that Vitamin D alone may decrease the risk of preeclampsia, low birth weight, and preterm birth. In addition, there was a suggestion that Vitamin D could increase head circumference and length at birth. However, when Vitamin D was given with calcium, the risk of preterm birth was increased. Furthermore, data on adverse outcomes remains limited. Rigorous RCTs are necessary prior to recommending routine use of Vitamin D in pregnancy.
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