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Grand Rounds

Do Twins or Singletons Have a Higher Rate of Preterm Mortality?

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PURPOSE:

This study by Vasak et al. (AJOG, 2016) sought to determine if there is a higher rate of mortality during the perinatal period among preterm births in singletons versus twin pregnancies.

METHODS:

Cohort study from the nationwide Netherlands Perinatal Registry

RESULTS:

1,502,120 singletons and 51,658 twin pregnancies delivered after 28 weeks’ gestation were surveyed. In twin pregnancies the overall perinatal mortality rate was increased, as expected (6.6/1000 vs 4.1/1000) when compared to singleton pregnancies. However, when only the preterm period was analyzed, the risk of perinatal mortality in singletons was higher than in twins (34.5/1000 vs 10.4/1000). The authors propose a hypothesis that this finding of superior outcomes in the preterm period among twins may reflect additional monitoring and that perhaps closer surveillance could benefit singletons as well.

Learn More – Primary Sources:

Lower perinatal mortality in preterm born twins than in singletons: a nationwide study from The Netherlands

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Related ObG Topics:

SMFM Statement: Choice of Progestogen for Preterm Birth Prevention
Is Neural Function Compromised Prior to Preterm Birth?
(Cochrane 2016) Vitamin D During Pregnancy and Adverse Pregnancy Outcomes

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