Does Smoking During Pregnancy Affect the Fetal Immune System?
This study by Chahal et al. (Nicotine and Tobacco Research, 2016) aimed to determine if maternal smoking can affect the child’s immune system, as altered immune function can have long term impact throughout life.
Observational cohort study using data from Upstate KIDS Study (collaboration between NICHD and New York State and University of Albany to track growth and development of children).
3,459 singletons and twins in the Upstate KIDS Study were surveyed. Newborn dried blood spots were used to measure levels of interleukin, IL-1 receptor antagonist, Il-6, IL-8, C-reactive protein, tumor necrosis factor alpha, and immunoglobulins (IgE, IgA, IgM, and IgG subclasses). Generalized estimating equations were used to calculate mean differences in biomarker levels by timing of pregnancy smoking, amount of cigarette consumption, and exposure to secondhand smoke. 344 women reported smoking during pregnancy, and around 40% continued throughout their pregnancies. IL-8 levels were significantly increased in children born from smoking mothers. Children born to women who stopped smoking during their pregnancies did not have elevated levels of IL-8. This study reinforces the importance of helping pregnant women stop smoking even if late in pregnancy.
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan