Interpregnancy Interval and Adverse Perinatal Outcomes
This study by Hanley et al. (Obstetrics & Gynecology, 2017) aimed to analyze the relationship between interpregnancy interval and adverse pregnancy outcomes.
Retrospective Cohort Study, using successive pregnancies to serve as matched controls
38,178 women with three or more deliveries were surveyed. Pregnancy interval was compared to neonatal outcomes including preterm birth (< 37 weeks’ gestation), small for gestational age (< 10th centile), need for neonatal intensive care and low birth weight (<2,500 g). Maternal outcomes were also assessed and included gestational diabetes, preeclampsia / eclampsia, and obesity (BMI ≥ 30). When women served as their own controls based upon successive pregnancies, many adverse outcomes disappeared, suggesting that study design may explain the different findings in some previous studies. Short interpregnancy (0 to 5 months) interval was still associated with higher risk of beginning subsequent pregnancies with elevated BMIs in the obese range as well as GDM.
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