For Physicians. By Physicians.™
For Physicians. By Physicians.™
This study by Yefet et al. (BJOG, 2017) aimed to compare on-demand vs. fixed-interval of oral analgesics following c-section for pain relief, safety and patient satisfaction.
Randomized Controlled Trial (RCT)
200 women who had undergone C-sections with regional anesthesia were randomly assigned to receive predetermined combinations of tramadol (opioid), paracetamol (acetaminophen), and diclofenac (NSAID) either on-demand or every six hours (for the first 48 hours). If greater pain relief was required, Percocet was given as a rescue treatment. Self-evaluation was used to determine pain intensity and satisfaction, visual analog scales of 0 (no pain, least satisfaction) to 10 (worst pain, highest satisfaction). Breastfeeding, need for supplemental formula, and any adverse maternal and neonatal effects were also evaluated. The fixed interval group had lower mean pain scores than the on-demand group (2.8 ± 0.84 vs. 4.1 ± 0.48), as well as higher satisfaction scores (9.1 ± 1.2 vs. 8.3 ± 1.5), more breastfeeds (23.7 ± 6.5 versus 19.2 ± 6.2), and lower uses of formula (8.2 ± 5.2 versus 11.9 ± 6.5). The women in the fixed-interval group did ingest more drugs, but this did not lead to a corresponding increase in serious adverse maternal or neonates outcomes.
Please log in to ObGFirst to access the 2T US Atlas
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
