This study by Groom et al. (AJOG, 2017) aimed to determine if enoxaparin, a low molecular weight heparin blood thinner, can be used to prevent preeclampsia and small-for-gestational-age pregnancy in women who have a prior history of these conditions.
Randomized Clinical Trial (RCT)
149 women with a history of preeclampsia or small-for gestational-age pregnancy were enrolled in the study. 77 received standard high-risk care, and 72 received high-risk care as well as a subQ injection of 40mg (4000 IU) enoxaparin daily from time of enrollment to delivery or 36 weeks’ gestation (whichever came first). Enoxaparin did not reduce the risk of preeclampsia and small-for-gestational-age neonates in women with a history of these complications.
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