This study by Imtiaz et al. (Neurology, 2017) aimed to illuminate the relationship between postmenopausal hormone replacement therapy (HT) and Alzheimer’s disease.
Prospective Cohort study
Data was obtained from the 20 year Kuopio Osteoporosis Risk Factor and Prevention study. 8,195 women, 227 with Alzheimer’s, were surveyed. There was no associated risk found for postmenopausal use of estrogen and Alzheimer’s disease. Women who self-reported as having a long history of HT use had lower incidence of Alzheimer’s and other dementia diagnoses. However, no strong evidence was found for HT protecting against Alzheimer’s disease.
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