This study by Blumenfeld et al. (AJOG, 2014) examined the relationship between placental abruption, maternal characteristics, and routine first- and second-trimester aneuploidy screening analytes.
Population-Based Cohort Study
1,017 women with placental abruption, and 136,898 women without who had first and second trimester prenatal screening results were surveyed. Aneuploidy screening analytes and maternal characteristics were analyzed using logistic binomial regression. Women of Asian descent, those older than 34 years of age, women with chronic and pregnancy-associated hypertension, preexisting diabetes, preeclampsia, previous preterm birth, and an interpregnancy interval of less than 6 months all had more frequent rates of placental abruption. When taking in to account the presence or absence of hypertensive disease, the three factors that remained significantly associated with placental abruption: (1) maternal age older than 34 years, and the two analytes (2) PAPP-A in ≤ 5th percentile and (3) AFP ≥ 95th percentile.
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