Geometric mean concentration of maternal anti-S antibodies was higher after ≥3 doses (P<0.001)
2 doses: 674 (95% CI, 577 to 787)
≥3 doses: 8159 (95% CI, 6636 to 10,032)
Geometric mean concentration of cord anti-S antibodies was also higher after ≥3 doses (P<0.001)
2 doses: 1000 (95% CI, 874 to 1144)
≥3 doses: 9992 (95% CI, 8381 to 11,914)
After adjustment for vaccine timing and number of doses before delivery, no association was found between preterm delivery and cord anti-S antibody levels
β 0.44 (95% CI, −0.06 to 0.94)
Cord antibody levels seem to be dictated by maternal antibody concentration, rather than gestational age at delivery
The authors state
However, with the current primary COVID-19 vaccine series no longer available and a recent Advisory Committee on Immunization Practices recommendation for a single vaccine dose for all individuals, further study is warranted regarding COVID-19 vaccine dosing to provide optimal maternal and infant COVID-19 antibody protection
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