SARS-CoV-2 antibodies detected at time of delivery
Maternal sera: 6% (95% CI, 5% to 7%)
Cord sera from the pregnancies with positive maternal antibodies: 87% (95% CI, 78% to 93%)
In cord sera
When antibody present, only IgG detected
No antibodies detected in cord sera if mother was seronegative
11 infants born to seropositive mothers were seronegative
Born to mother with IgM only: 45%
Born to mothers with significantly lower IgG concentrations: 55%
Cord blood IgG concentrations were positively correlated with maternal IgG concentrations (P < 0.001)
Placental transfer ratios of more than 1.0 were observed among women with asymptomatic SARS-CoV-2 infections as well as those with mild, moderate, and severe COVID-19
Transfer ratios increased with increasing time between onset of maternal infection and delivery
Neonates born to seropositive mothers had IgG antibodies to SARS-CoV-2
Antibody positive cord sera also documented among asymptomatic pregnancies
Antibody concentrations in cord blood correlated with
Maternal antibody concentrations
Duration between onset of infection and delivery
The authors conclude
Our findings demonstrate the potential for maternally derived antibodies to provide neonatal protection from SARS-CoV-2 infection and will help inform both neonatal management guidance and design of vaccine trials during pregnancy
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