The absence of the expected effect of lower glycemia on microvascular complications has been noted in some trials, including studies of diabetes prevention, and this absence has been ascribed to inadequate separation of glycemic levels over time, insufficient trial duration, threshold effects, or inadequate power
Any or all of these factors, including the small separation in glycemia might have been operative in our trial
Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes
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