Does Maternal COVID-19 Vaccination Protect Against Infant Hospitalization Due to COVID?
BACKGROUND AND PURPOSE:
Halasa et al. (CDCMMWR, 2022) assessed the effectiveness of maternal completion of a 2-dose mRNA COVID-19 vaccination series during pregnancy against COVID-19 hospitalization in infants
Test-negative, case-control study
Real-world evaluation at 20 US pediatric hospitals during a period of Delta and Omicron variant circulation
Infants aged <6 months admitted outside of their birth hospitalization to a pediatric hospital during July, 2021 to January, 2022
Case infants had a positive COVID-19 test
Control infants had a negative COVID-19 test
Maternal vaccination ≥14 days before delivery
Defined as completion of a 2-dose series of either Pfizer-BioNTech or Moderna mRNA COVID-19 vaccine
Control-infants were matched to case-infants by site and were hospitalized within 3 to 4 weeks of a case-infant’s admission date
In a secondary analysis, effectiveness of maternal receipt of the second dose of COVID-19 vaccination early in pregnancy (within the first 20 weeks) and late in pregnancy (21 weeks through 14 days before delivery) was assessed
Vaccine effectiveness (VE) of maternal vaccination against infant COVID-19 hospitalization
Case infants: 176 | Control infants: 203
Median age 2 months
Had at least one underlying medical condition: 21%
Born premature (<37 weeks): 22%
Effectiveness of maternal vaccination during pregnancy against COVID-19 hospitalization in infants aged <6 months
VE: 61% (95% CI, 31 to 78%)
Effectiveness of a completed 2-dose COVID-19 vaccination series early in pregnancy (first 20 weeks)
VE: 32% (95% CI, –43% to 68%)
Effectiveness of vaccine completion late in pregnancy (21 weeks through 14 days before delivery)
VE: 80% (95% CI, 55 to 91%)
Maternal COVID-19 immunization appears to provide protection to infants through passive transplacental antibody transfer
Maternal vaccination had a VE of 61% for preventing COVID-19 hospitalization in infants
The authors state
Overall, these findings indicate that maternal vaccination during pregnancy might help protect against COVID-19 hospitalization among infants aged <6 months
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