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COVID-19 Research Summaries

Can Vaccination Lead to Improved Long-COVID Symptoms?

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BACKGROUND AND PURPOSE: 

  • Risk factors and disease progression of Long-COVID or post-acute sequelae of SARS-CoV-2 infection are not well understood 
    • It isn’t clear whether vaccination can help prevent or improve symptoms of long-COVID 
  • Nehme et al. (Journal of General Internal Medicine, 2022) described the association of vaccination and the evolution of six cardinal symptoms embodying post-acute sequelae of SARS-CoV-2  

METHODS: 

  • Survey based study 
  • Participants 
    • Individuals who previously tested positive for SARS-CoV-2 infection (RT-PCR test) at a testing center in Switzerland  
    • Survey was sent between April 23 to July 27, 2021 
  • Exposures 
    • Post-acute sequelae of SARS-CoV-2 
    • Vaccination status 
  • Study design 
    • At the time of the study, the public health recommendations in Switzerland were for previously infected individuals to preferably receive one dose of vaccination only 
  • Primary outcome 
    • Persistence of symptoms  
      • Fatigue | Difficulty concentrating or memory loss | Loss of or change in smell | Loss of or change in taste | Shortness of breath | Headache 

RESULTS: 

  • 2094 participants 
    • Vaccinated, one dose: 26.6% 
    • Vaccinated, two doses: 20.5% 
  • Symptom status following vaccination 
    • Symptoms disappeared: 30.8% 
    • Symptoms improved: 35.5% 
    • Symptoms remained stable: 28.7% 
    • Symptoms worsened: 3.3% 
  • Vaccination (one or two doses) was associated with a decreased prevalence of the six cardinal post-SARS-CoV-2 symptoms 
    • Adjusted odds ratio (aOR) 0.72 (95% CI, 0.56 to 0.92) 
  • Vaccination with 2 doses was associated with a decreased prevalence of 
    • Dyspnea: aOR 0.34 (95% CI, 0.14 to 0.82) 
    • Change in taste: aOR 0.38 (95% CI, 0.18 to 0.83) 
    • Any one symptom: aOR 0.60 (95% CI, 0.43 to 0.83) 

CONCLUSION: 

  • Compared to no vaccination, participants who were vaccinated reported improvement in post-acute SARS-CoV-2 sequelae 
  • The authors state 

If confirmed, this would mean that vaccination not only prevents infection but also can potentially improve post-acute sequelae of SARS-CoV-2 

Learn More – Primary Sources: 

Symptoms After COVID-19 Vaccination in Patients with Post-Acute Sequelae of SARS-CoV-2 

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Related ObG Topics:

Long-COVID Features and Related Clinical Factors
COVID-19 mRNA Vaccine Effectiveness in the Real World Including in Those Partially Immunized
Are the Presence of Post-Vaccination Symptoms Associated with COVID-19 Vaccine Effectiveness?

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