COVID-19 Vaccination and Miscarriage: Another Study Finds No Link
BACKGROUND AND PURPOSE:
Magnus et al. (NEJM, 2021) assessed the association between COVID-19 vaccination and miscarriage
Cases: Women who had a miscarriage <14 weeks of gestation
Controls: Women with a primary care–based confirmation of ongoing pregnancy in the first trimester
Odds ratios (OR) for COVID-19 vaccination within 5-week and 3-week windows before a miscarriage or ongoing pregnancy
Adjustments: Age | Country of birth | Marital status | Educational level | Household income | Number of children | Employment in a health care profession | Underlying risk conditions for Covid-19 | Previous test positive for SARS-CoV2 | Calendar month
Odds of COVID-19 vaccination before a miscarriage
Cases: 4521 women | Controls: 13,956 women
Vaccinations in cases: 5.5%
Vaccinations in controls: 5.1%
Median number of days between vaccination and miscarriage or confirmation of ongoing pregnancy: 19 days
There was no association between vaccination and miscarriage
Within 3 weeks of vaccination: OR 0.91 (95% CI, 0.75 to 1.10)
Within 5 weeks of vaccination: OR 0.81 (95% CI, 0.69 to 0.95)
The results were similar in an analysis that
Included all available vaccine types
Stratified according to the number of doses received
women who were healthcare personnel
Women with ≥8 weeks of follow-up after confirmed pregnancy (to exclude subsequent pregnancy loss)
There is no evidence that COVID-19 vaccination during pregnancy is associated with increased odds of miscarriage in the first trimester
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