Does Preimplantation Genetic Testing for Monogenetic Diseases Increase the Risk of Pregnancy Complications?
BACKGROUND AND PURPOSE:
Feldman et al. (Obstetrics & Gynecology, 2020) examined whether preimplantation genetic testing for monogenic diseases (PGT-M) is associated with a higher risk of pregnancy complications vs IVF without preimplantation genetic testing or spontaneously conceived pregnancies
All pregnancies conceived after preimplantation genetic testing for monogenic diseases
Compared to patients who (1) conceived spontaneously or (2) conceived with IVF but without preimplantation testing
PGT-M group: Preimplantation genetic testing for monogenic diseases
IVF group: IVF without preimplantation genetic testing
Control: spontaneous conception
Obstetric outcomes were compared between groups
Multivariable regression modeling use to assess relationships between PGT-M and adverse outcomes
Covariates included in the analyses
Age | BMI | Smoking history | parity | Mode of conception | Indication for PGT-M
PGT-M is associated with a higher rate of hypertensive disorders when adjusted for confounders
Spontaneous conception: 2.3%: aOR 14.8 (95% CI, 7.4 to 29.8)
IVF: 4.7%: aOR 5.9 (95% CI 1.9 to 18.2)
PGT-M was associated with a higher rate of small-for-gestational age (SGA) neonates
Spontaneous conception: 3.9% | aOR 2.3 (95% CI 1.5 to 3.4)
IVF: 4.5% | aOR 2.5 (95% CI, 1.7 to 5.2)
PGT-M was also associated with an increased rate of hypertensive disorders
Spontaneous conception: 4.3% | aOR 10.9 (95% CI 2.3 to 50)
IVF: 4% | aOR 3.7 (95% CI 1.1 to 12.8)
Preimplantation genetic testing for monogenic diseases was associated with an increased risk for hypertensive disorders of pregnancy and SGA vs IVF without preimplantation testing or spontaneous conception
There were no differences detected for other complications
Study limitations include lack of information regarding
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