PURPOSE:

• The UK Obstetric Surveillance System (UKOSS) is a research registry system, funded by the National Institute for Health Research in 2012 to prepare in case of a pandemic
  • Due to COVID-19, UKOSS was activated in March 2020
• Researchers based at the University of Oxford, in collaboration with RCOG, the Universities of Leeds and Birmingham, Kings and Imperial Colleges London studied the current risk factors and outcomes among pregnant women with SARS-CoV-2 infection who were hospitalized on maternity units from all 194 hospitals in the UK

METHODS:

• UKOSS National prospective observational cohort study (March 1 to April 14, 2020)
• Participants (exposed group)
  • Pregnant women admitted to hospital with confirmed SARS-CoV-2 infection
• Comparison cohort
  • 2 women giving birth immediately prior to any woman with confirmed influenza (derived from a previous study that analyzed influenza in pregnancy between November 1, 2017 and October 30, 2018)
  • This comparison (control) cohort was used to avoid confusing ‘non-SARS-CoV-2’ patients with those who may be infected but were asymptomatic
• Primary outcome
  • Incidence of maternal hospitalization and infant infection
  • Rates of maternal death, level 3 critical care unit admission, preterm birth, stillbirth, early neonatal death, perinatal death
• Statistical analysis
  • Based on number of patients in study and comparison cohort: 80% power at p<0.05 could detect a ≥1.5 difference of a more common risk factor (with 25% prevalence in comparison group) and ≥2 difference for a risk factor with 5% prevalence

RESULTS:

• Study cohort: n=427 | Comparison group: n= 694 women
  • Most common presenting symptoms were fever, cough, and breathlessness
  • 247 (58%) gave birth or had a pregnancy loss | Remaining 180 (42%) of cases are ongoing
• Estimated incidence of hospitalization with confirmed SARS-CoV-2 in pregnancy: 4.9/1000 maternities (95% CI, 4.5 to 5.4)
• The median gestation at symptom onset: 34 weeks (IQR 29- 38)
• Risk factors for admission during pregnancy
  • Black or other minority ethnicity: adjusted odds ratio (aOR) 4.49 (95% CI, 3.37 to 6.00)
  • Older maternal age (>35 years): aOR 1.35 (95% CI, 1.01 to 1.81)
  • Overweight (BMI ≥25): aOR 1.91 (95% CI, 1.37 to 2.68)
  • Obesity (BMI ≥30): aOR 2.20 (95% CI, 1.56 to 3.10)
  • Preexisting Medical Condition: aOR 1.52 (95% CI, 1.12 to 2.06) | Included asthma, hypertension, cardiac disease and diabetes
  • Patients were less likely to be smokers
• Of patients giving birth during the study, 73% delivered at term
• Preterm: 63 patients
  • 79% were iatrogenic (50 cases): 46% due to maternal COVID-19 | 14% due to fetal compromise 19% for other obstetric conditions
• Cesarean: 59%
  • Maternal compromise: 27%
  • Fetal compromise: 24%
  • Failure to progress or failed induction: 19%
  • Other obstetrical reasons: 15%
  • Previous cesarean: 11%
  • Maternal request: 4%
• Mothers requiring respiratory support: 9% (40 women)
• Infants testing positive for SARS-CoV-2: 5% (12 infants) | 6 within 12 hours after birth | 4 delivered by cesarean including 3 pre-labor
• Fetal and newborn loss
  • 3 stillbirths (2 unclear if related to COVID-19)
  • 2 neonatal deaths (definitely not related to COVID-19)
• Newborn ICU admission: 26 infants
  • Preterm: 72%

CONCLUSION:

• Most patients had good outcomes that generally tracked with general non-pregnant population
  • Clinical course: Approximately 10% ventilatory support
  • Risk factors: Strong association with comorbidities
• Transmission uncommon but may occur
• Hospitalizations were in late second and third trimester
• >60% cesarean rate: Majority for indications other than maternal compromise due to COVID-19
• The authors emphasize the association between black and minority ethnicity and hospitalization for COVID-19
  • This association was not explained by geography and remained after adjusting for age, BMI and co-morbidities and “is of concern and requires further investigation”

Learn More – Primary Sources:

Characteristics and outcomes of pregnant women hospitalised with confirmed SARS-CoV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS)

RCOG and RCM respond to UKOSS study of more than 400 pregnant women hospitalised with coronavirus

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