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#Grand Rounds

Can Resistance Training Exercise Reduce Menopausal Hot Flushes?

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BACKGROUND AND PURPOSE:

  • Exercise has been suggested as a treatment option for hot flushes, but evidence is limited as to effectiveness  
    • Previously, most research focused on aerobic and low-impact exercise vs resistance training
    • Resistance training may work via activation of central β-endorphin production following activation of large muscle groups
  • Berin et al. (Maturitas, 2019) studied impact of resistance training on the frequency of moderate to severe postmenopausal hot flushes

METHODS:

  • Randomized, controlled trial (RCT)
  • Participants
    • ≥4 moderate or severe hot flushes or night sweats per day
    • At baseline: No regular exercise or use of therapy for hot flushes two months prior to study entry
  • Intervention: 15-week resistance training
    • Performed 3x per week
    • The program contained 8 exercises performed with 8–12 repetitions in 2 sets
      • Chest press | Leg press | Seated row | Leg curl | Latissimus dorsi pull-down | Leg extension | Crunches and back raises
    • Loads were set individually from eight-repetition maximum-strength tests and increased progressively
  • Primary outcome
    • Change in mean moderate or severe hot flushes per day from baseline to week 15
    • Assessed with symptom diaries
  • Secondary outcomes
    • Change in hot flush score
    • Time spent on physical activity
  • Statistical analysis
    • 40 participants needed to detect a 50% difference in moderate and severe HF with 80% power and an expected dropout rate of 20%
    • Increased to 60% to allow for secondary outcomes analysis

RESULTS:

  • 58 women completed the trial: 29 in intervention group | 29 in control group
    • Mean age: 55 years
    • Mean number of moderate or severe hot flushes per day at baseline: 7.1 (no difference between groups)
  • The frequency of hot flushes decreased more in the intervention group than in the control group
    • Mean difference: −2.7 (95% CI, −4.2 to −1.3)
  • Mean percentage change in hot flushes was significantly higher in the exercise group (P <0.001)
    • Intervention group: -43.6% (95% CI, −56.0 to −31.3)
    • Control group: −2.0% (95% CI, −16.4–12.4)

CONCLUSION:

  • Postmenopausal women who completed a 15-week resistance-training program experienced fewer moderate and severe hot flushes
  • Resistance-training could be an effect and safe treatment option for reducing hot flushes in postmenopausal women
  • Results can only be generalized to an otherwise healthy postmenopausal population

Learn More – Primary Sources:

Resistance training for hot flushes in postmenopausal women: A randomised controlled trial

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Related ObG Topics:

North American Menopause Society: Hormone Therapy Statement
What Hormone Profile is Associated with Hot Flashes?
Can Mindfulness Alleviate Menopausal Hot Flashes?
How Does Exercise Affect Health Postmenopause?

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