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#Grand Rounds

Can Daughters Inherit a Predisposition Towards Stillbirth from Their Mothers?

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BACKGROUND AND PURPOSE:

  • Previous studies have suggested heritable predisposition, mother to daughter, may exist for certain pregnancy complications such as preeclampsia
  • It is unknown if risk of stillbirth is also heritable
  • Woolner et al. (AJOG, 2019) investigated whether there is a heritable predisposition to stillbirth from mother to daughter

METHODS:

  • Nested case-control study (1949–2016)
  • Participants
    • Intergenerational cohort
    • All mothers with at least 1 daughter
    • Multiple pregnancies excluded due to inherent increased risk of stillbirth
    • Mother-daughter pairs were linked with the use of the Scottish Community Health Index number
  • Exposure
    • Mother’s history of stillbirth
    • Mother’s history of miscarriage
  • Cases and controls:
    • Cases: Daughters with a history of ≥1 stillbirth
    • Controls: Daughters who delivered only liveborn infants
  • Primary outcome
    • Stillbirth in any of the daughter’s pregnancies
  • Data Analysis
    • Estimated odds ratio (OR) was calculated  
    • Multi-adjusted analyses were performed to include cofounders at the daughters’ pregnancy level

RESULTS:

  • 26,788 unique mother-daughter pairs were included
    • Cases: 384 daughters had a history of ≥1 stillbirths
    • Controls: 26,404 daughters only ever had livebirths
  • No statistically significant association between mothers’ history of stillbirth or miscarriage and stillbirth in daughters
    • Mothers’ history of stillbirth: adjusted OR 0.63 (95% CI, 0.24–1.63)
    • Mother’s history of miscarriage: adjusted OR 1.01 (95% CI, 0.71–1.42)

CONCLUSION:

  • Nested case-control model used because stillbirth is such a rare outcome
  • This is the first large study to look at heritability of stillbirth
    • Results consistent with previous research that did not find heritable predisposition of placental dysfunction
  • Results do not support a heritable predisposition for stillbirth between mother and daughter

Learn More – Primary Sources:

Inherited predisposition to stillbirth: an intergenerational analysis of 26,788 mother-daughter pairs

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Related ObG Topics:

Results from the MiNESS Trial: Does Supine vs Left-Sided Sleeping Position Impact Risk of Stillbirth?
How Well Can Perceived Changes in Fetal Movements Predict Stillbirth?
How Do Maternal Age and Pregnancy History Affect Risk of Miscarriage?
Risk of Stillbirth with Intrahepatic Cholestasis of Pregnancy: What do Bile Acid Concentrations Tell Us?

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