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Grand Rounds

MMR Vaccine and Autism: Another Major Study Demonstrating No Link

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BACKGROUND AND PURPOSE:

  • Haviid et al. (Annals of Internal Medicine, 2019) examined whether measles, mumps, rubella (MMR) vaccine increases risk of autism

METHODS:

  • Nationwide cohort study
    • Children born in Denmark
    • Born 1999-2010
    • Follow-up from 1 year of age through 2013
  • Linked registries
    • MMR vaccines | Autism diagnoses | Other childhood vaccines | Sibling history of autism | other Autism risk factors

RESULTS:

  • 657,461 children | 5,025,754 person-years of follow-up
    • 6,517 children were diagnosed with autism
    • Incidence rate: 129.7 per 100,000 person-years
  • 625,824 vaccinated | 31,619 unvaccinated
    • No significant differences in vaccine uptake based on sex, birth cohort, autism risk score, or autism history in siblings
  • Mean attained age in the study: 8.64 years
  • No differences detected in MMR-unvaccinated children vs vaccinated children for autism risk
    • Adjusted autism hazard ratio (HR) 0.93 (95% CI, 0.85 to 1.02)
  • There was no increased risk for autism in children that received MMR vaccination when subgroups and time periods were analyzed
    • Sibling history of autism
    • Autism risk factors (disease risk score)
    • Other childhood vaccinations
    • Specified time periods after vaccination

CONCLUSION:

  • The authors state

We found no support for the hypothesis of increased risk for autism after MMR vaccination in a nationwide unselected population of Danish children; no support for the hypothesis of MMR vaccination triggering autism in susceptible subgroups characterized by environmental and familial risk factors; and no support for a clustering of autism cases in specific time periods after MMR vaccination.


Learn More – Primary Sources:

Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study

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Aluminum and Vaccines – The Evidence for Continuing Safety
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Prenatal Ultrasound and Autism: Is There a Connection?

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