MMR Vaccine and Autism: Another Major Study Demonstrating No Link
BACKGROUND AND PURPOSE:
Haviid et al. (Annals of Internal Medicine,
2019) examined whether measles, mumps, rubella (MMR) vaccine increases risk of
Nationwide cohort study
Children born in Denmark
Follow-up from 1 year of age through 2013
MMR vaccines | Autism diagnoses | Other childhood vaccines | Sibling history of autism | other Autism risk factors
657,461 children | 5,025,754 person-years of
6,517 children were diagnosed with autism
Incidence rate: 129.7 per 100,000 person-years
625,824 vaccinated | 31,619 unvaccinated
No significant differences in vaccine uptake based
on sex, birth cohort, autism risk score, or autism history in siblings
Mean attained age in the study: 8.64 years
No differences detected in MMR-unvaccinated
children vs vaccinated children for autism risk
Adjusted autism hazard ratio (HR) 0.93 (95% CI,
0.85 to 1.02)
There was no increased risk for autism in
children that received MMR vaccination when subgroups and time periods were
Sibling history of autism
Autism risk factors (disease risk score)
Other childhood vaccinations
Specified time periods after vaccination
The authors state
We found no support for the hypothesis of increased risk for autism after MMR vaccination in a nationwide unselected population of Danish children; no support for the hypothesis of MMR vaccination triggering autism in susceptible subgroups characterized by environmental and familial risk factors; and no support for a clustering of autism cases in specific time periods after MMR vaccination.
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