High dose (n-249 exposed) adjusted OR: OR 3.20 (95% CI, 2.73–3.75)
Major Malformations (overall)
No associated risk with first trimester exposure
Cardiac septal closure anomalies
Increaed risk with high dose exposure during the first trimester
Adjusted OR 1.81 (95% CI, 1.04–3.14)
Stillbirth: No associated risk
Fluconazole exposure in pregnancy may increase risk of spontaneous abortion
Dose > 150 mg in first trimester may increase risk of cardiac septal closure anomalies
Professional bodies urge caution in prescribing fluconazole in pregnancy advise that other alternative antifungal agents be used to treat candidiasis in pregnancy (see ‘Learn More’ and ‘Related ObG Topics’ below)
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan