Baseline HPV Status and Risk for Future CIN2+ Cytology
Genotyping for HPV improves risk stratification when cytology is negative for intraepithelial lesions or malignancy (NILM)
Fröberg et al. (Cancer, 2019) sought to determine
Odds of developing high-grade CIN based on baseline HPV status
Impact of HPV genotyping based on the age (using the 30-year-old threshold)
Nested case-control study
Data extracted from the Swedish cervical screening program
96 CIN2+ cases
5 age-matched controls per case
Baseline samples tested with liquid-based cytology and also tested for HPV
14 HPV types studied, including 16 and 18
Age <30 years
HPV 16/18 was strongly associated with risk for subsequent CIN2+
16/18: Odds ratio (OR) 9.44 (95% CI, 3.37-26.4)
Other HPV types were not found to be significantly associated with future CIN2+
Age ≥30 years
Both 16/18 and other HPV types were strongly associated with risk for subsequent CIN2+
16/18: OR 8.16 (95% CI, 3.28-20.3)
Other types: OR 9.04 (95% CI, 3.42-23.9)
Baseline positive HPV status in women NILM is highly associated with future high risk CIN2+
HPV types 16 and 18 are strongly associated with risk in women <30, while both 16/18 and other HPV types have a significant risk impact on women ≥30 years of age
The authors call for more research and state
Accurate knowledge of HPV, CIN, and cervical cancer is indispensable, especially among women at increased cervical cancer risk and as cervical cancer screening becomes increasingly reliant on HPV testing.
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