Grand Rounds

Do Higher Serum FSH Levels Reduce Risk of Diabetes in Postmenopausal Women?

BACKGROUND AND PURPOSE:

There is limited data on the relationship between FSH levels and diabetes in women, especially those over 50 years of age
Cheung et al. (Maturitas, 2018) examined the association between serum FSH and diabetes risk in postmenopausal women

Database search and meta-analysis
- Women who participated in the Hong Kong Osteoporosis Study age ≥55 at baseline
Studies included those that had
- Data on serum FSH and incident diabetes
- A mean follow-up of 10.7 years

1,274 participants were included
- 60 cases of incident diabetes
Serum FSH was significantly associated with reduced risk of diabetes
- Hazard ratio [HR] per standard deviation (SD) increase: 0.66 (95% CI, 0.48-0.89; P = 0.007)
The result persisted after adjusting for confounding
- HR per SD increase: 0.70 (95% CI: 0.51-0.97; P = 0.030)
In a fixed effect meta-analysis of two studies
- Serum FSH > 50 IU/L was associated with reduced risk of diabetes
- HR 0.56 (95% CI, 0.36-0.85; P = 0.006)

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