In 1 case, US results remained normal (18 weeks) despite fetal abnormalities detected on MRI (abnormal ventricular zone and focal cerebral migration abnormality without microcephaly or ventriculomegaly seen on MRI)
Prolonged maternal polymerase chain reaction positivity was present in 1 case only
All 3 mothers had a postivie ZIKV IgG and palque-reduction neutralization assay
No prenatal abnormalities identified: 79 cases
MRI performed in 53 infants
7 (13%) had identifiable, mild abnormalities postnatally
US performed in 57 infants
21 (37%) had relatively mild abnormalities, including changes of lenticulostriate vasculopathy, choroid plexus cysts, germinolytic/subependymal cysts, and/or calcification
All US cases were not well categorized by MRI
All newborns had negative ZIKV PCR and IgM serologic test results
96% of fetuses with potential ZIKV exposure had normal prenatal imaging
Not well established yet that NTD is part of the ZIKV spectrum of disorders
In this study, fetal brain anomalies only occurred in 2% which is lower expected when there is symptomatic maternal infection in the first trimester
Authors propose the reason for this discrepancy may be the result of
Differences in case definitions
Environmental or genetic factors
Prenatal US examination appeared to detect all but 1 abnormal fetal case
Postnatal neuroimaging in infants who had normal prenatal imaging revealed new mild abnormalities and supports CDC recommendation for postnatal cranial US
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