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Grand Rounds

Is Cesarean Section Associated with Increased BMI in Offspring?

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BACKGROUND AND PURPOSE:

  • Previous meta-analyses suggested that cesarean section is associated with increased BMI in offspring
  • Confounding is a concern, even when adjusting for BMI
  • One approach is to use within-family sibling data to control for environmental factors and shared genetic background
  • Rifas-Shiman et al. (JAMA Pediatrics, 2018) sought to determine whether there is an association between mode of delivery and BMI of offspring

METHODS:

  • Retrospective cohort study
  • Data derived from the Linked CENTURY (Collecting Electronic Nutrition Trajectory Data Using Records of Youth) study
  • Model adjusted for
    • Maternal age | Parity| Race & ethnicity
    • Child’s age | Sex | Birth year
  • Data analyzed to assess within-family component and between-family component
  • Main exposure: Route of delivery
  • Primary outcomes: Age-specific and sex-specific BMI z-score (also called standard deviation score) at 5 years of age
    • BMI z-scores are measures of relative weight adjusted for child age and sex
    • 0.0 would represent 50th percentile BMI while 2.5 would be >99th percentile

RESULTS:

  • 16,140 siblings were included from 8070 mothers
    • 19.9% of children had cesarean delivery
    • Mean (SD) BMI z-score at 5 years of age was 0.48 (1.00)
  • Mean BMI z-score was
    • 0.45 among siblings who both had vaginal delivery
    • 0.51 among siblings with 1 cesarean and 1 vaginal delivery
    • 0.63 among siblings who both had cesarean delivery
  • In co-variate adjusted model, the within-family association of cesarean vs vaginal delivery was not significant
    • 0.04 higher BMI z-score at 5 years of age (95% CI, −0.04 to 0.11)
  • The addition of the between-family assessment changed association to 0.13 (95% CI, 0.04 to 0.22)
  • In a model adjusted for the same covariates, but without decomposing the within-family and between-family effects, children with cesarean delivery had 0.13 higher BMI z score (95% CI, 0.08 to 0.17)

CONCLUSION:

  • The authors found that within families, cesarean section was not associated with increase in BMI z-score at 5 years of age
  • The authors conclude that previous studies, which found association with obesity and increased weight was limited by confounding

Learn More – Primary Sources:

Association of Cesarean Delivery With Body Mass Index z Score at Age 5 Years

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Related ObG Topics:

Does Gestational Hypertension Increase Risk of Type 2 Diabetes in Adult Offspring?
Maternal Overweight, Obesity and Congenital Malformations – How Strong is the Link?

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