Does Gestational Hypertension Increase Risk of Type 2 Diabetes in Adult Offspring?
This study by Kajantie et al. (AJOG, 2017) sought to determine if fetal exposure to gestational hypertension and preeclampsia increases risk for type 2 diabetes later in life.
Retrospective Cohort Study
5,335 members of the Helsinki Birth Cohort Study were surveyed. 590 men (21.6%) and 433 women (16.9%) had purchased medication for diabetes (and were therefore considered to have diabetes). The hazard ratio for type 2 diabetes for offspring exposed to any type of maternal hypertension during pregnancy was 1.13, it was 1.15 for maternal gestational hypertension, and 0.98 for preeclampsia. Amongst offspring with onset of diabetes before 62 years of age, the corresponding hazard ratios were 1.25, 1.28, and 1.18, respectively. Hazard ratios were similar after adjusting for birthweight SD score for gestation, length of gestation, maternal BMI in late pregnancy, height, age, parity, and socioeconomic position. This study reiterates the role of all gestational hypertensive disorders on the health of offspring throughout life.
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