Is there a Genetic Link between Lynch Syndrome and Breast Cancer?
BACKGROUND AND PURPOSE:
Lynch syndrome (LS) is associated with several cancer types, including colon and ovarian cancer in women (see ‘Related ObG Topics for more clinical and genetic information on LS)
Studies on LS and breast cancer association have been conflicting
Roberts et al. (Genetics in Medicine, 2017) sought to determine if there is an association between (LS) and breast cancer
Retrospective review of personal and family history with pathogenic or likely pathogenic germ-line variants in
Mutations were identified using multigene hereditary cancer testing
Standard incidence ratios (SIRs) were calculated by comparing the number of observed cancers to the number of expected cancers based on breast cancer incidence in the general population
Data was collected from 423 women
Age-standardized breast cancer risks
MSH6: Statistically significant increased SIR 2.11; 95% CI 1.56–2.86
PMS2: Statistically significant increased SIR 2.92; 95% CI, 2.17–3.92
There was no association observed for MLH1 or MSH2
Overall, breast cancer risk was twofold higher in the LS cohort but only in 2 genes, MSH6 (31.1% cumulative risk for breast cancer by age 60) and PMS2 (37.7% cumulative risk for breast cancer by age 60)
Women with pathogenic variants in MSH6 and PMS2 have a modest but statistically increased risk of breast cancer and may benefit from increased surveillance for breast cancer
Please sign up or log in to your ObGFirst to access this Premium Content
Media - Internet
Computer System Requirements
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
NOT ENOUGH CME HOURS
It appears you don't have enough CME Hours to take this Post-Test. Feel free to buy additional CME hours or upgrade your current CME subscription plan