This study by Scheller et al. (NEJM, 2017) aimed to determine if exposure to the quadrivalent HPV vaccine during pregnancy leads to adverse outcomes.
Matched case control study
Data from pregnant women in Denmark between 2006-2013 were extracted from national registries. Women who had been vaccinated during pregnancy were matched against women who had not been vaccinated in a 1:4 ratio. No increased risk was found for birth defects, spontaneous abortion, preterm birth, low birth weight, small size for gestational age or stillbirth. The authors conclude that exposure of quadrivalent HPV vaccine in pregnancy is safe and not associated with higher risk for adverse outcomes.
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