Low-dose (81 mg) aspirin is recommended by USPSTF to reduce cardiovascular disease and colorectal cancer. As previous studies were inconclusive on the role of aspirin in the prevention of breast cancer, the aim of this study by Clarke et al. (Breast Cancer Res, 2017) was to determine whether hormone receptor subtypes (HR) and Her-2/neu receptor (HER2) status may be responsible for the variability in previous studies.
Observational Longitudinal Cohort: This study assessed data collected over several years from the California Teachers Study cohort. The cohort began in 1995-1996 and initially included 133,479 women, followed with baseline and ongoing annual questionnaires on family history and other cancer risk factors. The 2005-2006 questionnaire incorporated use of aspirin and other pain medications. In addition, the above data was linked to the California Cancer Registry and Office of Statewide Health Planning and Development which provides information on hospital services.
Key findings include:
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