For Physicians. By Physicians.™
For Physicians. By Physicians.™
This study by Wong et al. (EBioMedicine, 2017) aimed to find a rapid and more accurate test for the Zika virus (ZIKV) using multiplex microsphere immunoassay (MIA).
Laboratory Validation Study
153 patient specimens with ZIKV and/or dengue virus (DENV) were tested. This study found that ZIKV enveloped-based MIA is at least as sensitive as IgM-capture ELISA (the standard diagnostic tool) in diagnosing ZIKV. The antibody response to the viral nonstructural proteins NS1 and NS5 is more specific to ZIKV than the antibody response to envelope protein alone. Including these proteins in the MIA increases the diagnostic accuracy. This diagnosis is also rapid, with a turnaround time of less than four hours, and requires only 10μl for a single reaction.
A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis
Please log in to ObGFirst to access the 2T US Atlas
OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, or Real Networks Real One Player.
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information
presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Jointly provided by
