Healthcare providers should report suspected Zika virus disease cases to their state, local, or territorial health department to facilitate diagnosis and mitigate risk of local transmission. State, local, and territorial health departments should report laboratory-confirmed and probable cases to CDC.
The following is a summary of CDC testing protocols. For detailed protocols and information, the CDC resource pages can be found in the Learn More – Primary Sources section below
Symptomatic individuals with possible exposure to Zika virus
Testing for Zika virus is available using molecular and serological assays. Typical symptoms include acute onset of fever, with maculopapular rash, arthralgia, myalgia, headache, conjunctivitis. Differential diagnosis of such symptoms is broad and include group A strep, rubella, measles and other viral diseases. Therefore, to identify those at risk for Zika virus, it is essential to take a travel and sexual history of all patients presenting with the above symptoms and to stay current with CDC updates as to high Zika virus transmission areas.
Tests for Zika virus include the following
Molecular Testing: Triplex Real-time RT-PCR Assay (rRT-PCR)
Antibody Detection Methods: Zika virus IgM
PRNT (Plaque Reduction Neutralization Test) to confirm antibodies
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