CDC Guidance for Non-Pregnant Patients and Available Diagnostic Tests for Zika Virus
Zika virus disease is a nationally notifiable condition:
Healthcare providers should report suspected Zika virus disease cases to their state, local, or territorial health department to facilitate diagnosis and mitigate risk of local transmission. State, local, and territorial health departments should report laboratory-confirmed and probable cases to CDC.
The following is a summary of CDC testing protocols. For detailed protocols and information, the CDC resource pages can be found in the Learn More – Primary Sourcessection below
Testing Guidance for Non-Pregnant patients
Symptomatic individuals with possible exposure to Zika virus
CDC defines ‘exposure’ to Zika virus as travel or residency in an area of active Zika virus transmission or sexual intercourse without a condom with a parter who has lived in or traveled to such an area
Concurrent testing of serum and urine by Zika virus ribonucleic acid (RNA) nucleic acid testing (NAT) and Zika virus and dengue virus IgM testing of serum is recommended
NAT testing is dependent on the timing of specimen collection
NAT testing should be performed on specimens collected <14 days after symptom onset
NAT testing is not recommended on specimens collected ≥ 14 days after symptom onset
Zika virus and dengue virus IgM serology testing should be performed on NAT negative samples collected <14 days after onset of symptoms or on samples collected ≥14 days after onset of symptoms
Testing for Zika virus is available using molecular and serological assays. Typical symptoms include acute onset of fever, with maculopapular rash, arthralgia, myalgia, headache, conjunctivitis. Differential diagnosis of such symptoms is broad and include group A strep, rubella, measles and other viral diseases. Therefore, to identify those at risk for Zika virus, it is essential to take a travel and sexual history of all patients presenting with the above symptoms and to stay current with CDC updates as to high Zika virus transmission areas.
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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