While most children will be asymptomatic or exhibit mild symptoms, SARS-CoV-2 infection has been temporally associated with a syndrome now labeled by the CDC as Multisystem Inflammatory Syndrome in Children (MIS-C). It was first identified in the UK. The underlying mechanism for this severe inflammatory syndrome is not yet understood, but some speculate that the antibody following illness may be generating an overly vigorous immune response in these children and teens. MIS-C can appear weeks after initial infection. According to the CDC, “there have been very few cases of death reported in hospitalized patients”.
Case Definition for MIS-C
The RCPCH expert panel add that
It’s very important to keep this in perspective. It’s a very rare condition and because of that parents shouldn’t be alarmed. We’re talking about a really small number of cases, each of which was picked up and treated by experts in our health system. It remains extremely unlikely that a child will become unwell with COVID-19, and it’s even more unlikely that a child will become unwell with this condition.
CDC: Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C)
CDC: Multisystem Inflammatory Syndrome (MIS-C)
NYSDOH: Health Advisory: Pediatric Multi-System Inflammatory Syndrome Potentially Associated with Coronavirus Disease (Covid-19) In Children
Royal College of Paediatrics and Child Health Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19
Royal College of Paediatrics and Child Health: Leading paediatricians publish case definition for illness affecting children during COVID-19
NYC 2020 Health Alert #13: Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19
NEJM: Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
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