On May 17, 2018, the FDA approved erenumab, the first drug to prevent migraines by targeting and blocking the activity of calcitonin gene-related peptide (CGRP-R), an important molecule involved in migraine attacks. Studies demonstrated that using monthly self-administered injections, migraine sufferers experienced a reduction in monthly migraine days (see data below under ‘Supporting Studies’)
FDA approval based on 3 studies
FDA approves novel preventive treatment for migraine
Prescribing Information for Aimovig
Migraine is a complex neurologic event encompassing moderate to severe headache as well as systemic and neurologic symptoms. Treatment is aimed at both amelioration of symptoms as well as prevention of attacks. Dosage below is based on the Lancet (2018) review and International Headache Society (IHS) guidelines but may vary based on a patient’s medical and clinical circumstances.
Note: The FDA has approved medications for treatment of migraine with and without aura, based on new classes of drugs (see ‘Primary Sources – Learn More’ below)
Notes: (Canadian Headache Society Guidelines)
Treatment of migraines is intended to reduce the acute symptoms as well as prevent future events. A multitude of medical therapies are available to this end. When starting therapy begin with the lowest dose and escalate slowly. A 2-3 month trial is necessary to determine efficacy. 6 months may be needed to achieve maximal result.
Mother To Baby: Sumatriptan Fact Sheet
FDA HIGHLIGHTS OF PRESCRIBING INFORMATION: UBRELVY (ubrogepant)
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