Advanced maternal age (AMA) was historically defined as women who will be ≥35 years at estimated date of delivery (EDD). There has been a continued upward trend in the mean age of pregnant individuals in the US and globally. AMA is associated with adverse maternal, fetal, neonatal adverse outcomes, with progressive age-related risks. ACOG in collaboration with SMFM, provide evidence-based clinical recommendations for obstetric care in this population. The document notes the fact that 35 years is an arbitrary threshold, and some outcomes may not be of concern until 40 years of age or later.
Note: Sex chromosome trisomies (XXX, XXY, XYY) increase with maternal age but rates of 45X (Turner syndrome) does not
35 to 39 Years
Mode of Delivery
ACOG Obstetric Care Consensus 11: Pregnancy at Age 35 Years or Older
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