Does ART increase the risk for imprinting disorders such as BWS?
BACKGROUND AND PURPOSE:
There have been reports of an association between assisted reproductive techniques (ART) and imprinting disorders, for example (clinical findings and management for syndromes can be found in ‘Learn More – Primary Sources below)
Beckwith-Wiedemann syndrome (BWS)
Mussa et al. (Pediatrics, 2017) examined the prevalence of Beckwith-Wiedemann syndrome (BWS) in children born through ART to further refine relative risk
BWS patients were identified and matched with general demographic data and corresponding regional ART registry
BWS criteria included at least 2 of the following
Abdominal wall defect, macroglossia, macrosomia, embryonal tumor, ear malformations, organ enlargement, nevus flammeus, hemihyperplasia, nephron/urological malformations, hypoglycemia, or family history of BWS
Out of a total population of 379,872 live births, 7884 ART live births were studied
Within the total population, there were 38 patients with BWS (7 from ART and 31 naturally)
BWS birth prevalence was significantly higher in the ART group
In the ART group the relative risk was higher in BWS compared to non-ART at 10.7 (887.9 per 1,000,000 vs 83.3 per 1,000,000 risk)
There is an approximately ten-fold increased risk of BWS in ART children
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