SMFM has released a Consult Series entry on Intrahepatic Cholestasis of Pregnancy (ICP), that typically presents in the second and third trimester of pregnancy. It is characterized by pruritus without rash, as well as elevated bile acids. The incidence is 0.3 to 0.5% and varies between populations. The risks are mostly fetal, including prematurity and IUFD.
History and Physical
Order Serum Bile Acids & LFTs
Neonatal Adverse Outcomes
Maternal Adverse Outcome
Ursodeoxycholic acid does not seem to have any significant clinical benefit when used routinely for treatment of women with intrahepatic cholestasis of pregnancy
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