Endometrial intraepithelial neoplasia (EIN) is the precursor of type I endometrioid adenocarcinoma.
There are three categories in the EIN classification:
Criteria for diagnosing endometrial intraepithelial neoplasia include the following:
Endometrial hyperplasia can be a precursor to adenocarcinoma of the endometrium. Distinguishing between hyperplasia and a precancerous lesion is important in optimizing management. The endometrial intraepithelial neoplasia (EIN) classification described here is intended to achieve this, while incorporating pathologic criteria that have become available since the World Health Organization’s 1994 four-class classification was developed.
ACOG Committee Opinion No. 631: Endometrial intraepithelial neoplasia
Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systemic review and meta-analysis
Levonorgestrel-releasing intrauterine system vs oral progestins for non-atypical endometrial hyperplasia: a systematic review and metaanalysis of randomized trials
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