Endometrial cancer is the most common gynecologic malignancy in the US and accounts for 7% of all cancers in women. Most cases are diagnosed early and can be treated with surgery alone. with surgery alone. However, there are certain cell types and clinical features (such as extrauterine spread) that are associated with a high rate of relapse following surgical and medical therapy. There are two types of endometrial cancer that vary in epidemiology, genetics, treatment, and prognosis.
Types of Endometrial Cancer
Type 1 (more common): Endometrioid
Precursor is atypical endometrial hyperplasia (or endometrial intraepithelial neoplasia)
Most cases are low grade
Generally results from unopposed, prolonged estrogen stimulation
Unopposed estrogen |Age| Obesity | Metabolic syndrome | Nulliparity | Infertility | Late menopause | Tamoxifen use | Type 2 diabetes | Hypertension | Lynch syndrome
Note: Tamoxifen risk may be related to age and is significant in women ≥50 years of age (NSABP prevention trial in high risk women)
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