Endometrial cancer is the most common gynecologic malignancy in the US and accounts for 7% of all cancers in women. Most cases are diagnosed early and can be treated with surgery alone. with surgery alone. However, there are certain cell types and clinical features (such as extrauterine spread) that are associated with a high rate of relapse following surgical and medical therapy. There are two types of endometrial cancer that vary in epidemiology, genetics, treatment, and prognosis.
Type 1 (more common): Endometrioid
Note: Tamoxifen risk may be related to age and is significant in women ≥50 years of age (NSABP prevention trial in high risk women)
Type 2: Papillary serous | Clear cell| Carcinosarcoma (Mixed Mullerian Tumor [MMT])
Note: If biopsy has been performed and is benign, yet bleeding persists, dilation and curettage plus hysteroscopy is needed
Postmenopausal Women
Asymptomatic Premenopausal Women
Patient outcomes are improved when high-volume surgeons in high-volume institutions render care, and this outcomes model typically is reproduced by standard gynecologic oncology practice
ACOG/ SGO Practice Bulletin 149: Endometrial Cancer
NCI: Endometrial Cancer – Health Professional Version
Executive Summary of the Uterine Cancer Evidence Review Conference
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