Sickle cell disease is a common genetic condition that affects the function of adult hemoglobin. It has a high prevalence in people with African, Middle Eastern, and West Indian ancestry. Any pregnant woman who reports a high-risk ethnicity should be screened with hemoglobin electrophoresis, which is highly accurate in detecting carriers of sickle cell trait. Many reproductive carrier screening genetic panels also include screening for sickle cell carrier status. (For more on screening, see ‘Related ObG Topics’ below).
Sickle Cell Disease / Sickle Cell Anemia
Sickle Cell Trait / Sickle Cell Carrier
ACOG Committee Opinion 691: Carrier Screening for Genetic Conditions
GeneReviews: Sickle Cell Disease
Hematopoietic Stem Cell Gene-Addition/Editing Therapy in Sickle Cell Disease
Maternal Fetal Medicine Specialist Locator-SMFM
American Society of Hematology
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