RCT Results: Does a New Antibiotic Combination Lead to Clinical Cure for Complicated UTI or Acute Pyelonephritis?
BACKGROUND AND PURPOSE:
New therapeutic drug combinations are needed for treatment of complicated urinary tract infection (UTI) and other infections, due to the increased prevalence of resistant bacteria
Cefepime/enmetazobactam is a novel β-lactam/β-lactamase inhibitor combination and a potential therapy for gram-negative resistant infections
Kaye et al. (JAMA, 2022) assessed whether cefepime/enmetazobactam was noninferior to piperacillin/tazobactam (Zosyn) for treatment efficacy in patients with complicated urinary tract infections (UTIs) or acute pyelonephritis
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Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
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presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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